Department of Experimental, Diagnostic and Specialty Medicine, St. Orsola-Malpighi Hospital, Haematological and Oncological Institute, University of Bologna, 9 Massarenti street, 40138, Bologna, Italy. giovanni.brandi@unibo.it. Department of Experimental, Diagnostic and Specialty Medicine, St. Orsola-Malpighi Hospital, Haematological and Oncological Institute, University of Bologna, 9 Massarenti street, 40138, Bologna, Italy. Department of Medical and Surgical Sciences, St. Orsola-Malpighi Hospital, University of Bologna, 40138, Bologna, Italy. Department of Medicine, Bologna Health Authority, 40139, Bologna, Italy. Department of Digestive Diseases and Internal Medicine, St. Orsola-Malpighi Hospital, University of Bologna, 40138, Bologna, Italy.